1styr-B1 BIOCHEMISTRY QUESTIONS

 BIOCHEMISTRY
IMPORTANT QUESTIONS

CELL

1)Function performed by each of the following in one line 

     a)Cholesterol in membrane 

     b)Peroxisomes

     c)Lysosomes

     d)Posphotidylinistiol in membrane 

     e)Carbohydrates in membrane

 

2)Enumerate the functions of the endoplasmic reticulum?

3)components of the membrane with functions.

4)Role of G proteins in signal transduction.

5)Draw and label the structure of the cell membrane.

6)Differentiate Between nucleus, Golgi apparatus, endoplasmic reticulum, lysosomes, and mitochondria on the basis of functions.

 

TRANSPORT 

 

1)Classify transport across the cell membrane with special emphasis on primary active transport and secondary active transport. 

2)Explain secondary active transport across the cell membrane.

3)Define Osmotic pressure and describe the importance of osmotic pressure exerted by plasma proteins.

4)What is the importance of osmotic pressure exerted by collide osmotic pressure.

5)Classify particles with examples.

6)Define :  a)Viscosity  b)Surface tension

AMINOACIDS

1)What are different ways of classification of amino acids, explain with an example.

2)Define and enumerate essential amino acids. 

3) Classify amino acids on basis of polarity.

PROTEINS 

1)Briefly describe :

    a)Glutathione 

    b)Ampholse 

    c)Compound proteins

2)Explain the structure of protein along with its characteristics.

3)Quaternary structure of proteins with examples.

4)Tertiary structure.

5)Draw a table to show the concentration,  and types of globin chains of all haemoglobins present in adults and fetal blood along with the significance of HbA1c.

6)Classify proteins on the basis of functions.

PBQ :

   60 years old patient developed anxiety, depression, memory loss, and impaired thinking, and also difficulty in balance and co-ordination. He died of pneumonia within a year of developing these neurological symptoms . He was diagnosed with a case of prion disease.

      a)Name the disease in humans.

      b)Describe infective agents and structural changes of proteins.

FIBROUS PROTEINS

PBQ :

 A 9-month-old child fell over and was presented with a swollen leg. Imaging revealed a fracture of the bowed femur, secondary to minor trauma and thin bones . At age of one month, the infant had multiple fractures, family has ruled out child abuse as a cause of bone fracture.

      a)Which pair of defective molecules and resulting pathology is the cause.

      b)Describe the structure and synthesis of biomolecules.

1. Explain the Collagen synthesis process

2. note or PBQ on the ehler's danlos syndrome or osteogenesis imperfecta (Collegenopathies)

3. what is the role of alpha1 antitrypsin in lungs?

GLOBULAR PROTEINS

1. draw and explain the Hb dissociation curve, and note down the factors which shift the curve to the right or left side.

2. write a note on Bohr's effect.

3. what is meant by the P50 Value

4. A pbl on HbC HbS or HbSC diseases 

5. Write a note on HbA1c and write it's percentage value in body?

6. explain different kinds of Hb in the body.

(relaxed and taught structures for mcq's and viva important) 

IMMUNOGLOBULINS

1)Enumerate importance and give an account of any four of them.

2)Enumerate plasma proteins and give an account of any two immunoglobulins.

CARBOHYDRATES 

1)Classify carbohydrates with examples only on the basis of hydrolysis. 

2)Enumerate at least four homopolysaccharides. Explain the structure and function of starch.

3)Define polysaccharides and discuss GAGs .

4) Difference between starch and glycogen.

5)Discuss different types of isomers in carbohydrates with example.

6)Describe Glycosanion glycans with special emphasis on their biomedical significance.

7)Classify and define polysaccharides along with the basic structure and function of glycogen and dextran.

8)Discuss the biological significance of repair and hyaluronic acid.

9)Define Disaccharides and what is lactose intolerance.

10Write a note on lactose and draw its structure.

PH- AND PHYSIOLOGICAL PRINCIPLES

1)Define and enumerate body buffers.

2)Explain the biomedical significance of unusual or minor bases along with examples.

3)Define buffers and enlist body buffers that regulate pH to blood.

4)PH of blood must be maintained. Classify different types of buffers with composition in our bodies.

5)Define and classify buffer.

6)Give the importance of bicarbonate buffers.

7)Name 3 systems involved in the regulation of normal pH. Classify chemical buffers.

8)Write down the structural and functional properties of bicarbonate, phosphate, and protein buffers.

9)Explain the mechanism of buffer action.

10)Explain properties of buffers that maintain the pH of blood from 7.35 - 7.45.

HEMOGLOBIN CH 21 lippincott

1)Enlist steps in heme degradation.

2)Write down the site and regulatory steps of heme synthesis.

3)Define porphyrias.

4)Give classification of porphyrias.

5)Draw a flow chart explaining heme degradation.

6)Describe jaundice its types along with their causes and lab finding

Contributed by: Javeria Abbas ( creative director, 2nd year)
edited by: Aiza Anwar (PD, 2nd year)