2ndyr-B1 BIOCHEMISTRY GUIDE

 BIOCHEMISTRY GUIDE 
BLOCK 1

 

  For every topic I highly recommend going through the related videos on selfless medicos channel. Use Lippincott as the main book. The topics below are the only ones that get tested on SEQs, SAQs and vivas.

  Once done with a chapter, Go through the relevant past paper questions - they get repeated 90% of the time            

                                                

Bioenergetics and Oxidative Phosphorylation

1. Electron transport chain

---location

---Complexes

 ---Reactions and Coenzymes

2. Site specific Inhibitors of ETC (figure)

3. Chemiosmotic theory

---Pump

---ATP synthase (diagram + function) 

---Oxidative phosphorylation

---Oligomycin

---Uncouplers (natural + synthetic)

 

 

 Introduction to Carbohydrates

1. Digestion and absorption of carbs in GIT

---Mono,di and polysaccharides

----Enzymes and absorption (fig 7.9)

---Lactose Intolerance (diagram)

 

Introduction to Metabolism and Glycolysis

1. Glycolysis

---Transport into cells (GLUTs)

---**Reactions of glycolysis-all including diagrams, regulation, rate-limiting, deficiencies

---Lactate formation in anaerobic glycolysis (diagram + acidosis)

---Difference b/w aerobic and anaerobic (specially ATP production)

---Fates of pyruvate (3)

 Introduction to Metabolism and Glycolysis 

1.  Diagram at the end of chapter. (summary)

---add enzymes to it.

---ATP production 

Glycogen Metabolism

1. **Glycogenolysis (reactions, enzymes etc). Id recommend doing it along with a video on it made by selfless medicos.

2. ***Glycogenolysis

---Reactions

---Enzymes

---GLYCOGEN STORAGE DISEASE (v imp)

> Allosteric regulation of glycogen degradation and synthesis in Liver and muscle (diagram would be sufficient)

Metabolism of Monosaccharides and Disaccharides

1.  Fructose Metabolism

----Reactions (diagram sufficient)

----Disorders

----Hexokinase and its affinity (Km)

 

2.  Galactose metabolism

----Reactions (Diagram)

----Disorders

 

3. Lactose Synthesis

----Structural proteins, enzymes, diagram ( view selfless medicos)

Pentose Phosphate Pathway and
Nicotinamide Adenine Dinucleotide 13 Phosphate

> Definitely watch selfless medicos for HMP shunt. (Perfectly explained according to our syllabus content

1. Irreversible reactions only

---Enzymes

---Intermediates & Products

----Locations

-----coenzymes

2. Uses of NADPH (Very high yield)

----All in detail

3. G6PD deficiency

---Effect on RBC

---Precipitating factors

thanking our senior for their valuable contribution!

contributed by: Asad Waseem (3rd year)

edited by: Aiza Anwar (publishing director)